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Fabp1tm1Bin
Targeted Allele Detail
Summary
Symbol: Fabp1tm1Bin
Name: fatty acid binding protein 1, liver; targeted mutation 1, Bert Binas
MGI ID: MGI:2664854
Synonyms: L-FABP-, LFABP-
Gene: Fabp1  Location: Chr6:71176863-71182018 bp, + strand  Genetic Position: Chr6, 32.14 cM
Alliance: Fabp1tm1Bin page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:83875
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprt1b-m3
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe entire coding region of the gene was replaced by a neomycin resistance marker and homologous recombination was confirmed by PCR. Absence of gene transcripts was determined by RT-PCR while absence of gene product was established by Western blot. (J:83875)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Fabp1 Mutation:  21 strains or lines available
References
Original:  J:83875 Martin GG, et al., Decreased liver fatty acid binding capacity and altered liver lipid distribution in mice lacking the liver fatty acid-binding protein gene. J Biol Chem. 2003 Jun 13;278(24):21429-38
All:  33 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory