Fabp1^tm1Bin
Targeted Allele Detail

Summary

• Symbol: Fabp1^tm1Bin
• Name: fatty acid binding protein 1, liver; targeted mutation 1, Bert Binas
• MGI ID: MGI:2664854
• Synonyms: L-FABP^-, LFABP^-
• Gene: Fabp1 Location: Chr6:71176863-71182018 bp, + strand Genetic Position: Chr6, 32.14 cM
• Alliance: Fabp1^tm1Bin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83875
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region of the gene was replaced by a neomycin resistance marker and homologous recombination was confirmed by PCR. Absence of gene transcripts was determined by RT-PCR while absence of gene product was established by Western blot. (J:83875)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Fabp1 Mutation: 21 strains or lines available

References

• Original: J:83875 Martin GG, et al., Decreased liver fatty acid binding capacity and altered liver lipid distribution in mice lacking the liver fatty acid-binding protein gene. J Biol Chem. 2003 Jun 13;278(24):21429-38
• All: 33 reference(s)