Tg(PSEN1*M146L)1Citr
Transgene Detail

Summary

• Symbol: Tg(PSEN1*M146L)1Citr
• Name: transgene insertion 1, Martin Citron
• MGI ID: MGI:2664250
• Synonyms: Tg(M146L)1, Tg(PSEN1-M146L)2Citr
• Transgene: Tg(PSEN1*M146L)1Citr Location: unknown
• Alliance: Tg(PSEN1*M146L)1Citr page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(PSEN1*M146L)1Citr expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PSEN1 (5663)

  Psen1

  (MGI:1202717)

  Transgene codes for a protein with a methionine to leucine mutation.

• Mutation details: A human PSEN1 cDNA sequence with an engineered methionine to leucine mutation at residue 146 (M146L) was used for the transgene. (J:83861)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:83861 Citron M, et al., Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. Nat Med. 1997 Jan;3(1):67-72
• All: 5 reference(s)