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Cfld4BALB/cJ
QTL Variant Detail
Summary
QTL variant: Cfld4BALB/cJ
Name: cystic fibrosis lung disease 4; BALB/cJ
MGI ID: MGI:2661744
QTL: Cfld4  Location: Chr7:118693381-118693530 bp  Genetic Position: Chr7, cM position of peak correlated region/allele: 63.78 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  BALB/cJ
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased lung fibrosis in female animals compared to C57BL/6J.
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:80598

216 (C57BL/6J-Cftrtm1Unc x BALB/cJ-Cftrtm1Unc)F2 animals were typed for 114 microsatellite markers at an average spacing of 15 cM to identify QTLs affecting cystic fibrosis-associated lung disease. Parental strain C57BL/6J-Cftrtm1Unc exhibits increased collagen deposition and alveolar interstitial thickening compared to BALB/cJ-Cftrtm1Unc. A QTL named Cfld1 (cystic fibrosis lung disease 1) mapped from 83 cM - 107 cM on mouse Chromosome 2 with a LOD score of 3.0 at D2Mit528 (87.4 cM). Cfld1 is associated with lung fibrosis with BALB/cJ-derived alleles exhibiting recessive inheritance. Cfld2 mapped from 61.5 cM - 74.1 cM on mouse Chromosome 6 with a LOD score of 3.4 at D6Mit198 (67 cM). BALB/cJ-derived alleles confer additively inherited lung fibrosis at Cfld2. Cfld3 mapped from 4.1 cM - 16.4 cM on mouse Chromosome 17 with a LOD score of 3.2 at D17Mit57 (7.6 cM). Cfld3 is associated with lung fibrosis in male animals with C57BL/6J-derived alleles exhibiting additive inheritance. Cfld4 mapped to 50.3 cM - 60 cM on mouse Chromosome 7 with a LOD score of 3.1 at D7Mit238 (53 cM). Cfld4 is associated with alveoli count in female animals with BALB/cJ-derived alleles exhibiting dominant inheritance.

References
Original:  J:80598 Haston CK, et al., Detection of modifier loci influencing the lung phenotype of cystic fibrosis knockout mice. Mamm Genome. 2002 Nov;13(11):605-13
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory