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QTL Variant Detail
QTL variant: Circp2CBA/J
Name: circadian photosensitivity 2; CBA/J
MGI ID: MGI:2661442
QTL: Circp2  Location: Chr17:12198329-12198453 bp  Genetic Position: Chr17, cM position of peak correlated region/allele: 8.14 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Strain of Specimen:  CBA/J
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased circadian photosensitivity compared to C57BL/6J. (J:80788)
Inheritance:    Dominant
View phenotypes and curated references for all genotypes (concatenated display).

Mapping and Phenotype information for this QTL, its variants and associated markers


218 animals from a (CBA/J-Pde6brd1/Pde6brd1 x C57BL/6J-Pde6brd1/Pde6brd1)F2 intercross were typed for 74 microsatellite markers at an average resolution of 15 cM to identify QTLs associated with circadian photosensitivity. Parental strain C57BL/6J-Pde6brd1/Pde6brd1 exhibits a greater phase shift of circadian rhythm locomotor activity when subjected to a monochromatic light pulse compared to parental strain CBA/J-Pde6brd1/Pde6brd1. Two significant QTLs were identified on mouse Chromosomes 12 and 17. Circp1 maps to 6 cM on Chromosome 12 with a LOD score of 3.5 at D12Mit170. CBA/J-derived alleles confer increased photosensitivity with recessive inheritance at Circp1. Circp2 maps to 10.5 cM on Chromosome 17 with a LOD score of 3.7 at D17Mit113. CBA/J-derived alleles confer increased photosensitivity with dominant inheritance at Circp2. A possible candidate gene for Circp2 is Junb. Further analysis revealed that Junb expression is significantly reduced in CBA/J-Pde6brd1/Pde6brd1 animals after exposure to light. Suggestive loci were also identified at 39.3 cM (D8Mit75, LOD=2.2) and 44 cM (D8Mit242, LOD=2.2) on mouse Chromosome 8, and at 23 cM (D12Mit54, LOD=2.7) on mouse Chromosome 12.

Original:  J:80788 Yoshimura T, et al., Mapping quantitative trait loci affecting circadian photosensitivity in retinally degenerate mice. J Biol Rhythms. 2002 Dec;17(6):512-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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