Lmr14^BALB/cHeA
QTL Variant Detail

Summary

• QTL variant: Lmr14^BALB/cHeA
• Name: leishmaniasis resistance 14; BALB/cHeA
• MGI ID: MGI:2661195
• QTL: Lmr14 Location: Chr2:103095716-103095823 bp Genetic Position: Chr2, cM position of peak correlated region/allele: 62.98 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: BALB/cHeA

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: Lmr14 was identified influencing IgE level in interaction with Lmr25 on mouse Chromosome 10. BALB/c homozygotes at Lmr25 and STS/A homozygotes at Lmr14 or combination of BALB/c homozygtes at these loci resulted in increased IgE levels. This allele also confer increased spontaneous in vitro splenocyte proliferation of Leishmania infected animals compared to STS/A.
• Inheritance: Other (see notes)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Notes

Lmr14 exhibits additive inheritance.

Homozygosity for BALB/cHeA alleles at Lmr12 and Lmr14 confers increased serum TNF-alpha. Eache locus has minimal effect by itself.

References

• Original: J:82717 Badalova J, et al., Separation and mapping of multiple genes that control IgE level in Leishmania major infected mice. Genes Immun. 2002 Jun;3(4):187-95
• All: 2 reference(s)