About   Help   FAQ
Targeted Allele Detail
Symbol: Portm2Wolf
Name: cytochrome p450 oxidoreductase; targeted mutation 2, C Roland Wolf
MGI ID: MGI:2656920
Synonyms: CPR-
Gene: Por  Location: Chr5:135698894-135764180 bp, + strand  Genetic Position: Chr5, 75.34 cM, cytoband G1
Alliance: Portm2Wolf page
Germline Transmission:  Earliest citation of germline transmission: J:82951
Parent Cell Line:  GK129 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsA floxed neo cassette was introduced into intron 4 and a single loxP site was introduced into intron 15 via homologous recombination. Transient expression of cre recombinase in correctly targeted ES cells resulted in deletion of the neo cassette and exons 5-15. (J:82951)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Por Mutation:  67 strains or lines available
Original:  J:82951 Henderson CJ, et al., Inactivation of the hepatic cytochrome p450 system by conditional deletion of hepatic cytochrome p450 reductase. J Biol Chem. 2003 Apr 11;278(15):13480-6
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
MGI 6.22
The Jackson Laboratory