Mptp1^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Mptp1^C57BL/6J
• Name: MPTP sensitivity 1; C57BL/6J
• MGI ID: MGI:2656755
• QTL: Mptp1 Location: Chr1:171632048-192681050 bp Genetic Position: Chr1, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers resistance to MPTP-induced substantia nigra neuron loss compared to Swiss Webster. (J:82236)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:82236

58 animals from either a (C57BL/6J x Swiss Webster)F2 intercross or a (C57BL/6J x Swiss Webster)F1 x Swiss Webster backcross were screened for 61 polymorphic markers (average resolution = 30 cM) to detect QTLs associated with MPTP-induced neuron loss. Parental strain C57BL/6J is susceptible to MPTP-induced neuron loss of the substantia nigra while parental strain Swiss Webster is resistant. A QTL named Mptp1 on mouse Chromosome 1 was identified with LOD=4.5 and a QTL range of 93.3 cM - 109.6 cM between D1Mit113 and D1Mit293. Surprisingly, C57BL/6J-derived alleles confer resistance to MPTP-induced neuron loss with a dominant mode of inheritance. Homozygosity for Swiss Webster-derived alleles at Mptp1 is associated with increased neuron loss.

References

• Original: J:82236 Cook R, et al., Identification of a single QTL, Mptp1, for susceptibility to MPTP-induced substantia nigra pars compacta neuron loss in mice. Brain Res Mol Brain Res. 2003 Feb 20;110(2):279-88
• All: 1 reference(s)