Fap^tm2Schn
Targeted Allele Detail

Summary

• Symbol: Fap^tm2Schn
• Name: fibroblast activation protein; targeted mutation 2, Andreas Schnapp
• MGI ID: MGI:2656736
• Synonyms: Fap^- lacZ
• Gene: Fap Location: Chr2:62331280-62404365 bp, - strand Genetic Position: Chr2, 35.85 cM
• Alliance: Fap^tm2Schn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74135
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of a portion of exons 4 and 5 with a lacZ-neo cassette via homologous recombination. The gene targeting event results in an in-frame fusion of exon 4 with the lacZ gene. Protein extracts from homozygous mutant embryos did not exhibit enzyme activity. (J:74135)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fap Mutation: 54 strains or lines available

References

• Original: J:74135 Niedermeyer J, et al., Expression of the fibroblast activation protein during mouse embryo development. Int J Dev Biol. 2001 Apr;45(2):445-7
• All: 5 reference(s)