Cd46^tm1Osb
Targeted Allele Detail

Summary

• Symbol: Cd46^tm1Osb
• Name: CD46 antigen, complement regulatory protein; targeted mutation 1, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:2654215
• Synonyms: CD46^-, Cd46^tm1Oka
• Gene: Cd46 Location: Chr1:194719134-194774557 bp, - strand Genetic Position: Chr1, 98.41 cM
• Alliance: Cd46^tm1Osb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82516
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of the first 3 exons with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis. (J:82516)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd46 Mutation: 37 strains or lines available

References

• Original: J:82516 Inoue N, et al., Disruption of mouse CD46 causes an accelerated spontaneous acrosome reaction in sperm. Mol Cell Biol. 2003 Apr;23(7):2614-22
• All: 2 reference(s)