Igh^tm1Mwg
Targeted Allele Detail

Summary

• Symbol: Igh^tm1Mwg
• Name: immunoglobulin heavy chain complex; targeted mutation 1, Martin Weigert
• MGI ID: MGI:2653306
• Synonyms: 3H9H/GL
• Gene: Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82329
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• Mutation details: The following amino acid subsitutions were introduced by homologous recombination: arginine to glycine at position 53 (R53G), isoleucine to tyrosine at position 57 (I57Y), and aspartic acid to glycine at position 64 (D64G). These mutations revert the coding sequence to the germline codons. (J:82329)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh Mutation: 47 strains or lines available

References

• Original: J:82329 Li H, et al., Regulation of anti-phosphatidylserine antibodies. Immunity. 2003 Feb;18(2):185-92
• All: 1 reference(s)