Tg(CEACAM5)2682Wzm
Transgene Detail

Summary

• Symbol: Tg(CEACAM5)2682Wzm
• Name: transgene insertion 2682, Wolfgang Zimmerman
• MGI ID: MGI:2652514
• Synonyms: 2682, CEAtg, CEA.Tg
• Transgene: Tg(CEACAM5)2682Wzm Location: unknown
• Alliance: Tg(CEACAM5)2682Wzm page

Transgene origin

• Strain of Origin: (C57BL/6 x CB6)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CEACAM5)2682Wzm expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CEACAM5 (1048)

  Ceacam2

  (MGI:1347246)

• Tg(CEACAM5)2682Wzm expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  CEACAM5 (1048)

  Ceacam2

  (MGI:1347246)

• Mutation details: This transgene expresses human carcinoembryonic antigen under the control of the endogenous human promoter. Expression of this transgene was detected in the tongue, esophagus, stomach, small intestine, cecum, colon and trachea, and at lower levels in the lung, testis and uterus of adult mice. (J:82361)

Tumor Data

List all tumor models in MMHCdb carrying Tg(CEACAM5)2682Wzm

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

One to two copies of the transgene integrated into the genome.

References

• Original: J:82361 Eades-Perner AM, et al., Mice transgenic for the human carcinoembryonic antigen gene maintain its spatiotemporal expression pattern. Cancer Res. 1994 Aug 1;54(15):4169-76
• All: 12 reference(s)