Tg(K5-Ptgs2)667Kmd
Transgene Detail

Summary

• Symbol: Tg(K5-Ptgs2)667Kmd
• Name: transgene insertion 667, Karin Muller-Decker
• MGI ID: MGI:2651675
• Synonyms: K5.COX-2/667
• Transgene: Tg(K5-Ptgs2)667Kmd Location: unknown
• Alliance: Tg(K5-Ptgs2)667Kmd page

Sparse hair and long nails in mice expressing Tg(K5-Ptgs2)

Show the 2 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: NMRI

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(K5-Ptgs2)667Kmd expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ptgs2 (MGI:97798)

• Mutation details: The transgene is composed of a full length Ptgs2 cDNA without the 3' untranslated region fused to a bovine keratin 5 (K5) promoter. The bovine K5 promoter was used to drive transgene expression in basal keratinocytes of the interfollicular epidermis and in basal cells of the pilosebaceous unit. Transgene expression was observed in keratinocytes of the interfollicular stratum basale, the outer root sheath (ORS) cells of hair follicles, and the epithelial lining of sebaceous glands. Transgene expression was confirmed by RT-PCR analysis of stratified epithelial tissues. (J:70039)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(K5-Ptgs2)667Kmd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Seven founder animals were constructed and bred successfully. The founders are designated lines 4, 19, 29, 663, 667, 675, and 678. Line 667 exhibits strong transgene expression.

References

• Original: J:70039 Neufang G, et al., Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7629-34
• All: 6 reference(s)