Oprm1^tm2Loh
Targeted Allele Detail

Summary

• Symbol: Oprm1^tm2Loh
• Name: opioid receptor, mu 1; targeted mutation 2, Horace H Loh
• MGI ID: MGI:2651421
• Gene: Oprm1 Location: Chr10:6708593-6988209 bp, + strand Genetic Position: Chr10, 1.85 cM, cytoband A2
• Alliance: Oprm1^tm2Loh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81978
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The endogenous allele was disrupted by the insertion of a targeting vector containing a missense mutation in exon 2 and an intron floxed neo cassette. Encoded protein was undetected by radioactive ligand receptor-binding assay. Oprm^tm2.1Loh was generated by in vivo excision of the floxed neo cassette from this allele. (J:81978)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Oprm1 Mutation: 53 strains or lines available

Notes

ES cell line = SP1.

References

• Original: J:81978 Yang W, et al., In vivo activation of a mutant mu-opioid receptor by antagonist: future direction for opiate pain treatment paradigm that lacks undesirable side effects. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):2117-21
• All: 1 reference(s)