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Slc15a2tm1Dsmi
Targeted Allele Detail
Summary
Symbol: Slc15a2tm1Dsmi
Name: solute carrier family 15 (H+/peptide transporter), member 2; targeted mutation 1, David E Smith
MGI ID: MGI:2451265
Synonyms: Pept2-
Gene: Slc15a2  Location: Chr16:36570539-36605324 bp, - strand  Genetic Position: Chr16, 25.97 cM
Alliance: Slc15a2tm1Dsmi page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:81906
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA fragment encompassing a portion of exon 1 and all of exons 2 and 3 was replaced by a lacZ-neo cassette inserted by homologous recombination. The deleted region encoded the first 112 amino acids. Transcript was undetected in homozygous mutant mice by Northern blot analysis of renal RNA and RT-PCR analysis of choroid plexus RNA. Western blot analysis indicated an absence of encoded protein in homozygous mutant kidney brush border vesicle preparations. (J:81906)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc15a2 Mutation:  64 strains or lines available
References
Original:  J:81906 Shen H, et al., Targeted disruption of the PEPT2 gene markedly reduces dipeptide uptake in choroid plexus. J Biol Chem. 2003 Feb 14;278(7):4786-91
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/02/2024
MGI 6.13
The Jackson Laboratory