Musk^tm1Vwi
Targeted Allele Detail

Summary

• Symbol: Musk^tm1Vwi
• Name: muscle, skeletal, receptor tyrosine kinase; targeted mutation 1, Veit Witzemann
• MGI ID: MGI:2449789
• Synonyms: MuSK^loxP
• Gene: Musk Location: Chr4:58285962-58374303 bp, + strand Genetic Position: Chr4, 31.87 cM
• Alliance: Musk^tm1Vwi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81566
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• LoxP sites were inserted into the introns flanking the region encoding the kinase domain. (J:81566)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Musk Mutation: 42 strains or lines available

References

• Original: J:81566 Sander A, et al., MuSK induces in vivo acetylcholine receptor clusters in a ligand-independent manner. J Cell Biol. 2001 Dec 24;155(7):1287-96
• All: 2 reference(s)