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Targeted Allele Detail
Symbol: Ntan1tm1Avar
Name: N-terminal Asn amidase; targeted mutation 1, Alexander Varshavsky
MGI ID: MGI:2449464
Synonyms: Ntan1-
Gene: Ntan1  Location: Chr16:13636709-13653315 bp, + strand  Genetic Position: Chr16, 9.64 cM
Alliance: Ntan1tm1Avar page
Germline Transmission:  Earliest citation of germline transmission: J:62140
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of exons 2-5 with a PGK-neo cassette via homologous recombination. Northern blot analysis detected no expression in brains of homozygous mutant animals, but testes mRNA contained transcripts which apparently lack the 5' half of the open reading frame. Whole mount in-situ hybridization analysis of E9.75 homozygous mutant embryos did not detect any gene expression. (J:62140)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 20 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ntan1 Mutation:  14 strains or lines available
Original:  J:62140 Kwon YT, et al., Altered activity, social behavior, and spatial memory in mice lacking the NTAN1p amidase and the asparagine branch of the N-end rule pathway. Mol Cell Biol. 2000 Jun;20(11):4135-48
All:  5 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory