Plcg2^tm1Kuro
Targeted Allele Detail

Summary

• Symbol: Plcg2^tm1Kuro
• Name: phospholipase C, gamma 2; targeted mutation 1, Tomohiro Kurosaki
• MGI ID: MGI:2449276
• Synonyms: PLC-gamma2^flox, PLCgamma2^flox
• Gene: Plcg2 Location: Chr8:118225030-118361881 bp, + strand Genetic Position: Chr8, 64.26 cM
• Alliance: Plcg2^tm1Kuro page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63744
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A single loxP site and a loxP-flanked neomycin selection cassette were inserted to flank the exon encoding the PIP-2 binding site. The neomycin selection cassette was removed by transient Cre expression in ES cells prior to the production of mice, leaving a single loxP element at the insertion site. (J:63744)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plcg2 Mutation: 73 strains or lines available

References

• Original: J:63744 Hashimoto A, et al., Cutting edge: essential role of phospholipase C-gamma 2 in B cell development and function. J Immunol. 2000 Aug 15;165(4):1738-42
• All: 8 reference(s)