Tg(CD2-RUNX2)1Mstw
Transgene Detail

Summary

• Symbol: Tg(CD2-RUNX2)1Mstw
• Name: transgene insertion 1, Monica Stewart
• MGI ID: MGI:2448745
• Synonyms: CD2-Cbfa1-G1, CD2-Runx2
• Transgene: Tg(CD2-RUNX2)1Mstw Location: unknown
• Alliance: Tg(CD2-RUNX2)1Mstw page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA/Ca)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CD2-RUNX2)1Mstw expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Runx2 (MGI:99829)

• Mutation details: The transgene consists of a 2.3 kb cDNA of a lymphoma-specific isoform (G1/p57) of RUNX2, and a human CD2 promoter. The human CD2 promoter was used to drive expression in T lymphocytes. Northern blot analysis of transgenic tissues revealed transgene expression in thymus, spleen, and mesenteric lymph node. Transgene expression was confirmed by Western blot analysis of thymocytes. (J:59021)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:59021 Vaillant F, et al., A full-length Cbfa1 gene product perturbs T-cell development and promotes lymphomagenesis in synergy with myc. Oncogene. 1999 Nov 25;18(50):7124-34
• All: 6 reference(s)