Hhex^tm1Ngu
Targeted Allele Detail

Summary

• Symbol: Hhex^tm1Ngu
• Name: hematopoietically expressed homeobox; targeted mutation 1, Tamio Noguchi
• MGI ID: MGI:2448661
• Synonyms: Hex^-
• Gene: Hhex Location: Chr19:37423289-37429179 bp, + strand Genetic Position: Chr19, 32.28 cM, cytoband D1
• Alliance: Hhex^tm1Ngu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65105
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of the translation initiation site, exon 1, and part of intron 1 with a PGK-neo cassette via homologous recombination. Absence of gene expression in homozygous mutant embryos was confirmed by RT-PCR analysis. (J:65105)

Expression

In Mice Carrying this Mutation:	58 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Hhex Mutation: 16 strains or lines available

References

• Original: J:65105 Keng VW, et al., Homeobox gene hex is essential for onset of mouse embryonic liver development and differentiation of the monocyte lineage. Biochem Biophys Res Commun. 2000 Oct 5;276(3):1155-61
• All: 1 reference(s)