Tg(APOA1-CETP)1Dsg
Transgene Detail

Summary

• Symbol: Tg(APOA1-CETP)1Dsg
• Name: transgene insertion 1, David S Grass
• MGI ID: MGI:2448658
• Synonyms: CETP4
• Transgene: Tg(APOA1-CETP)1Dsg Location: unknown
• Alliance: Tg(APOA1-CETP)1Dsg page

Transgene origin

• Strain of Origin: (C57BL/6J x SJL)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(APOA1-CETP)1Dsg expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  human	CETP (1071)

• Tg(APOA1-CETP)1Dsg expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  APOA1 (335)

  Apoa1

  (MGI:88049)

• Mutation details: The transgene consists of a human APOA1 promoter and a 1.5 kb human CETP cDNA sequence. Northern blot analysis showed that transgene expression is exclusive to the liver. (J:81002)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Two transgenic lines were created. Line CETP4 exhibits 3-fold enzyme activity and was used in most studies.

References

• Original: J:81002 Grass DS, et al., Transgenic mice expressing both human apolipoprotein B and human CETP have a lipoprotein cholesterol distribution similar to that of normolipidemic humans. J Lipid Res. 1995 May;36(5):1082-91
• All: 13 reference(s)