Cnmd^tm1Ska
Targeted Allele Detail

Summary

• Symbol: Cnmd^tm1Ska
• Name: chondromodulin; targeted mutation 1, Shigeaki Kato
• MGI ID: MGI:2448465
• Synonyms: Chm1^-, ChM-I^-
• Gene: Cnmd Location: Chr14:79875130-79899610 bp, - strand Genetic Position: Chr14, 42.74 cM, cytoband D3
• Alliance: Cnmd^tm1Ska page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81137
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The endogenous locus was disrupted by the insertion of a nonsense mutation in codon 21 (exon 1) and with the replacement of exon 3 with a neomycin selection cassette. Northern blot analysis of rib cartilage RNA and Western blot analysis of whole rib extract indicated an absence of normal transcript and protein in homozygous mutant mice. (J:81137)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cnmd Mutation: 24 strains or lines available

References

• Original: J:81137 Nakamichi Y, et al., Chondromodulin I is a bone remodeling factor. Mol Cell Biol. 2003 Jan;23(2):636-44
• All: 4 reference(s)