Mvp^tm1Wie
Targeted Allele Detail

Summary

• Symbol: Mvp^tm1Wie
• Name: major vault protein; targeted mutation 1, Erik A C Wiemer
• MGI ID: MGI:2447742
• Synonyms: MVP^-
• Gene: Mvp Location: Chr7:126586032-126613766 bp, - strand Genetic Position: Chr7, 69.26 cM, cytoband F4
• Alliance: Mvp^tm1Wie page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80831
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exons 5-7 with a neomycin resistance cassette via homologous recombination. Absence of gene expression was confirmed by Northern and Western blot analysis. Gene transcript was not detectable in liver RNA from homozygous mutant animals, and protein product was not observed in several tissues tested. (J:80831)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mvp Mutation: 58 strains or lines available

References

• Original: J:80831 Mossink MH, et al., Disruption of the murine major vault protein (MVP/LRP) gene does not induce hypersensitivity to cytostatics. Cancer Res. 2002 Dec 15;62(24):7298-304
• All: 4 reference(s)