Mybl1^tm1Epr
Targeted Allele Detail

Summary

• Symbol: Mybl1^tm1Epr
• Name: myeloblastosis oncogene-like 1; targeted mutation 1, E Premkumar Reddy
• MGI ID: MGI:2447613
• Synonyms: A-myb^-
• Gene: Mybl1 Location: Chr1:9737640-9770434 bp, - strand Genetic Position: Chr1, 2.08 cM
• Alliance: Mybl1^tm1Epr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:39632
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The DNA binding domain encoded by the endogenous locus was disrupted by the insertion of a neomycin selection cassette into exon 4. While Northern blot analysis of testicular tissue showed normal levels of transcript in heterozygous mice, no transcript was detected in homozygous mutant mice. Western blot analysis using a polyclonal antibody directed against the DNA binding domain confirmed the absence of normal protein in homozygous mutant mice. (J:39632)

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mybl1 Mutation: 33 strains or lines available

References

• Original: J:39632 Toscani A, et al., Arrest of spermatogenesis and defective breast development in mice lacking A-myb. Nature. 1997 Apr 17;386(6626):713-7
• All: 5 reference(s)