Tg(CAG-Ncoa6*)#Hwl
Transgene Detail

Summary

• Symbol: Tg(CAG-Ncoa6*)#Hwl
• Name: transgene insertion, Han-Woong Lee
• MGI ID: MGI:2447471
• Synonyms: DN1/m, Tg(ACTB-Ncoa6)2Hwl
• Transgene: Tg(CAG-Ncoa6*)#Hwl Location: unknown
• Alliance: Tg(CAG-Ncoa6*)#Hwl page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-Ncoa6*)#Hwl expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Ncoa6	N-terminal LXXLL motif is mutated to LXXAA to abolish receptor interactions

• Mutation details: This transgene consists of a hemagglutinin (HA)-tagged fragment of Ncoa6 encoding amino acids 849-929, in which the N-terminal LXXLL motif is mutated to LXXAA, under the control of the chicken beta-actin promoter linked to a human cytomegalovirus immediate-early enhancer (CAG). This mutation abolishes receptor interactions. Four lines were generated, however the pound symbol (#) is used when line is not specified and/or lines are pooled. (J:80609)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:80609 Kim SW, et al., Multiple developmental defects derived from impaired recruitment of ASC-2 to nuclear receptors in mice: implication for posterior lenticonus with cataract. Mol Cell Biol. 2002 Dec;22(24):8409-14
• All: 1 reference(s)