St3gal4^tm1Jxm
Targeted Allele Detail

Summary

• Symbol: St3gal4^tm1Jxm
• Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 4; targeted mutation 1, Jamey Marth
• MGI ID: MGI:2446674
• Synonyms: ST3Gal-IV^F
• Gene: St3gal4 Location: Chr9:34957872-35028160 bp, - strand Genetic Position: Chr9, 19.36 cM, cytoband A5.3
• Alliance: St3gal4^tm1Jxm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80884
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Single loxP sites flank exons 5 through 7. The floxed region encodes the large sialyl motif essential for nucleotide sugar binding and the enzymatic activity of the endogenous protein. (J:80884)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any St3gal4 Mutation: 26 strains or lines available

References

• Original: J:80884 Ellies LG, et al., Sialyltransferase ST3Gal-IV operates as a dominant modifier of hemostasis by concealing asialoglycoprotein receptor ligands. Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):10042-7
• All: 2 reference(s)