Trrap^tm1.1Zqw
Targeted Allele Detail

Summary

• Symbol: Trrap^tm1.1Zqw
• Name: transformation/transcription domain-associated protein; targeted mutation 1.1, Zhao-Qi Wang
• MGI ID: MGI:2446468
• Synonyms: Trrap^-
• Gene: Trrap Location: Chr5:144704547-144796588 bp, + strand Genetic Position: Chr5, 84.77 cM
• Alliance: Trrap^tm1.1Zqw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71950
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The exon encoding the beginning of the protein's kinase-like domain was deleted via in vitro Cre-mediated recombination in targeted ES cells between a single upstream loxP site and the 3' loxP site of a downstream loxP-flanked neo^r-tk cassette. The absence of homozygous progeny from crosses of mice heterozygous for this allele demonstrates functional disruption of the gene or protein. (J:71950)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Trrap Mutation: 160 strains or lines available

Notes

No mice derived from ES cells bearing the "floxed" allele from which only the neo-tk cassette had been deleted were recovered.

References

• Original: J:71950 Herceg Z, et al., Disruption of Trrap causes early embryonic lethality and defects in cell cycle progression. Nat Genet. 2001 Oct;29(2):206-11
• All: 5 reference(s)