Del(2Hoxd13)3Ddu
Targeted Allele Detail

Summary

• Symbol: Del(2Hoxd13)3Ddu
• Name: deletion, Chr 2, Denis Duboule 3
• MGI ID: MGI:2445974
• Synonyms: Del3Ddu, HoxD^del(d13), Hoxd^tm6Ddu
• Gene: Del(2Hoxd13)3Ddu Location: unknown Genetic Position: Chr2, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80084
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intergenic deletion
• Del(2Hoxd13)3Ddu involves 1 genes/genome features (Hoxd13) View all
• Mutation details: Hoxd13 and region XI were deleted via trans-allelic meiotic recombination (TAMERE). The deletion was accomplished by recombination of a single loxP site in the intergenic region between Evx2 and Hoxd13 (Evx2/Hoxd13^tm1.1Ddu) and a single loxP on the opposite chromosome in the intergenic region between Hoxd12 and Hoxd13 (Hoxd^tm3Ddu). (J:80084)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Del(2Hoxd13)3Ddu Mutation: 1 strain or line available

References

• Original: J:80084 Kmita M, et al., Evolutionary conserved sequences are required for the insulation of the vertebrate Hoxd complex in neural cells. Development. 2002 Dec;129(23):5521-8
• All: 5 reference(s)