Igs16^tm1Ddu
Targeted Allele Detail

Summary

• Symbol: Igs16^tm1Ddu
• Name: intergenic site 16; targeted mutation 1, Denis Duboule
• MGI ID: MGI:2445961
• Synonyms: Evx2/Hoxd13^tm3Ddu, HoxD^RXII-neo
• Gene: Igs16 Location: unknown Genetic Position: Chr2, Syntenic
• Alliance: Igs16^tm1Ddu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80084
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Mutation details: A 1.2 kb fragment, located between Evx2 and Hoxd13 and containing region 12, was replaced with a floxed neo cassette. Mice carrying this allele were bred with transgenic mice expressing cre recombinase to generate Evx2/Hoxd13^tm3.1Ddu. (J:80084)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igs16 Mutation: 1 strain or line available

References

• Original: J:80084 Kmita M, et al., Evolutionary conserved sequences are required for the insulation of the vertebrate Hoxd complex in neural cells. Development. 2002 Dec;129(23):5521-8
• All: 1 reference(s)