Tg(MMTV-Nras)1Pel
Transgene Detail

Summary

• Symbol: Tg(MMTV-Nras)1Pel
• Name: transgene insertion 1, Angel Pellicer
• MGI ID: MGI:2445863
• Synonyms: MMTV/N-ras^N
• Transgene: Tg(MMTV-Nras)1Pel Location: unknown
• Alliance: Tg(MMTV-Nras)1Pel page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(MMTV-Nras)1Pel expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Nras (MGI:97376)

• Mutation details: The transgene consists of a fusion between the MMTV-LTR and a genomic Nras sequence from exon 1 to part of exon 6. The MMTV-LTR was used to drive transgene expression. High levels of expression was observed in the salivary gland, mammary gland, and Harderian gland. Intermediate levels of expression was observed in the lung, prostate, testis, and ovary. Low levels of expression was detected in thymus, brain, muscle, skin, bone marrow, kidney, gut, and heart. Transgene expression was verified by Northern blot and RNase protection assay. (J:72258)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Two male transgenic founders designated 4 and 7, which transmitted the transgene to progeny, were created.

References

• Original: J:72258 Mangues R, et al., Tumorigenesis and male sterility in transgenic mice expressing a MMTV/N-ras oncogene. Oncogene. 1990 Oct;5(10):1491-7
• All: 7 reference(s)