Gdf10^tm1Sjl
Targeted Allele Detail

Summary

• Symbol: Gdf10^tm1Sjl
• Name: growth differentiation factor 10; targeted mutation 1, Sejin Lee
• MGI ID: MGI:2445719
• Synonyms: Bmp3b^-
• Gene: Gdf10 Location: Chr14:33645544-33658471 bp, + strand Genetic Position: Chr14, 20.8 cM
• Alliance: Gdf10^tm1Sjl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:56683
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 were replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded the mature carboxyl terminal of the protein. Northern blot analysis indicated an absence of normal transcript in homozygous mutant mice. (J:56683)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gdf10 Mutation: 30 strains or lines available

References

• Original: J:56683 Zhao R, et al., Characterization of GDF-10 expression patterns and null mice. Dev Biol. 1999 Aug 1;212(1):68-79
• All: 5 reference(s)