Tg(GFAP-SV40T)1Tvd
Transgene Detail

Summary

• Symbol: Tg(GFAP-SV40T)1Tvd
• Name: transgene insertion 1, Terry Van Dyke
• MGI ID: MGI:2445446
• Synonyms: TgGFAP-T121, TgGFAPT121, Tg(GFAP-T121)1Tvd
• Transgene: Tg(GFAP-SV40T)1Tvd Location: unknown
• Alliance: Tg(GFAP-SV40T)1Tvd page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgene consists of a 2.2 kb fragment of human GFAP promoter, active in central nervous system cells of the astrocyte lineage, and a mutant SV40 T antigen sequence, which contains a deletion for the small t antigen-specific splice signal and a deletion resulting in truncation of the large T antigen at amino acid 121. Transgene expression in central nervous system cells of the astrocyte lineage was observed by immunohistochemical staining of brain sections from transgenic animals. (J:77132)

Tumor Data

List all tumor models in MMHCdb carrying Tg(GFAP-SV40T)1Tvd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

10 out of 13 founder animals developed severe brain abnormalities and died by 7-9 days of age. This transgene differs from Tg(GFAP-TAg121)1Tvd, which is a derivative of Tg(GFAP-lacZ-TAg121)92Tvd, and contains a loxP site in place of a Cre deleted lacZ cassette.

References

• Original: J:77132 Xiao A, et al., Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation. Cancer Cell. 2002 Mar;1(2):157-68
• All: 1 reference(s)