Tg(GFAP-lacZ-TAg121)92Tvd
Transgene Detail

Summary

• Symbol: Tg(GFAP-lacZ-TAg121)92Tvd
• Name: transgene insertion 92, Terry Van Dyke
• MGI ID: MGI:2445445
• Synonyms: GZT121, Tg(GFAP-LacZ-T121)2Tvd), Tg(GFAP-SV40T)2Tvd, TgGZT121
• Transgene: Tg(GFAP-lacZ-TAg121)92Tvd Location: unknown
• Alliance: Tg(GFAP-lacZ-TAg121)92Tvd page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgene consists of a human GFAP promoter, an intervening floxed lacZ cassette, and a mutant SV40 T antigen sequence. The 2.2 kb fragment of human GFAP was used to direct transgene expression in central nervous system cells of the astrocyte lineage.The SV40 sequence contains a deletion for the small t antigen-specific splice signal and a deletion that results in truncation of the large T antigen at amino acid 121. Immunohistochemical staining of brain sections from transgenic animals showed expression of lacZ and not SV40 T121, as expected. (J:77132)

Tumor Data

List all tumor models in MMHCdb carrying Tg(GFAP-lacZ-TAg121)92Tvd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:77132 Xiao A, et al., Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation. Cancer Cell. 2002 Mar;1(2):157-68
• All: 3 reference(s)