Ugcg^tm3Rlp
Targeted Allele Detail

Summary

• Symbol: Ugcg^tm3Rlp
• Name: UDP-glucose ceramide glucosyltransferase; targeted mutation 3, Richard L Proia
• MGI ID: MGI:2445417
• Synonyms: Ugcg^Lacz
• Gene: Ugcg Location: Chr4:59189452-59222833 bp, + strand Genetic Position: Chr4, 32.44 cM, cytoband B3
• Alliance: Ugcg^tm3Rlp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80111
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A promoter-less IRES-lacZ-neo cassette was inserted into exon 8 via homologous recombination. Southern blot analysis was used to identify and confirm the correct gene targeting event in embryonic stem cells. (J:80111)

Expression

In Mice Carrying this Mutation:

9 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ugcg Mutation: 86 strains or lines available

References

• Original: J:80111 Yamashita T, et al., Early developmental expression of the gene encoding glucosylceramide synthase, the enzyme controlling the first committed step of glycosphingolipid synthesis. Biochim Biophys Acta. 2002 Dec 19;1573(3):236-40
• All: 1 reference(s)