Rr349^tm1.1Wgw
Targeted Allele Detail

Summary

• Symbol: Rr349^tm1.1Wgw
• Name: regulatory region 349; targeted mutation 1.1, William G Wood
• MGI ID: MGI:2445400
• Synonyms: delta R2, Hba/Mare^tm1.1Wgw, Mare^tm1.1Wgw, mHS -26^-, mHS -26KO, Nprl3^tm1.1Wgw
• Gene: Rr349 Location: Chr11:32200804-32201369 bp Genetic Position: Chr11, Syntenic
• Alliance: Rr349^tm1.1Wgw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80121
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1312 bp sequence containing the Hba erythroid regulatory element (HS -26), located in Nprl3 intron 4 and containing transcription factor binding elements for the hemoglobin alpha genes, was replaced with a loxP site flanked neomycin resistance gene cassette. The neo cassette was removed through subsequent cre-mediated recombination, after which Nprl3 expression was restored to normal. The open reading frame of Nprl3 remained undisrupted. (J:80121)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr349 Mutation: 0 strains or lines available

References

• Original: J:80121 Anguita E, et al., Deletion of the mouse alpha-globin regulatory element (HS -26) has an unexpectedly mild phenotype. Blood. 2002 Nov 15;100(10):3450-6
• All: 3 reference(s)