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Targeted Allele Detail
Symbol: Slc19a2tm1Gelb
Name: solute carrier family 19 (thiamine transporter), member 2; targeted mutation 1, Bruce D Gelb
MGI ID: MGI:2429761
Synonyms: Slc19a2-
Gene: Slc19a2  Location: Chr1:164076615-164092954 bp, + strand  Genetic Position: Chr1, 71.56 cM
Alliance: Slc19a2tm1Gelb page
Germline Transmission:  Earliest citation of germline transmission: J:79974
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsExon 2 was disrupted by the insertion of a neomycin selection cassette. An aberrantly spliced transcript lacking a 3' portion of exon 2 was identified in homozygous mutant mice by Northern blot analysis. A reduction in high affinity thiamin transport in erythrocytes indicated an absence of functional protein. (J:79974)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc19a2 Mutation:  22 strains or lines available
Original:  J:79974 Oishi K, et al., Targeted disruption of Slc19a2, the gene encoding the high-affinity thiamin transporter Thtr-1, causes diabetes mellitus, sensorineural deafness and megaloblastosis in mice. Hum Mol Genet. 2002 Nov 1;11(23):2951-60
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory