Aod1^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Aod1^C57BL/6J
• Name: autoimmune ovarian dysgenesis 1; C57BL/6J
• MGI ID: MGI:2429552
• QTL: Aod1 Location: Chr16:32130840-32523112 bp Genetic Position: Chr16, cM position of peak correlated region/allele: 22.55 cM
• QTL Note: genome coordinates based on the boundaries of the QTL region

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:25722

D3Tx, A/J and (D3Tx x A/J)F1 mice are susceptible to AOD (autoimmunne ovarian dysgenesis disease) whereas C57BL/6J mice are resistant thus allowing for the potenial to genetically map the disease within these strains. One hundred and forty-four D3Tx x (C57BL/6J x A/J)F1 x C57BL/6J backcross mice were generated. Based on chi square analysis significant linkage of AOD (gene symbol Aod1) with Chromsome 16 markers D16Mit58 (p = 0.00086) and D16Mit60 (p = 0.00086) was indicated. AOD is distinguished by 2 phenotypes, presence of anti-ovarian antibodies and oophoritis, which when analyzed independently also segregated with markers on Chromsome 16.

References

• Original: J:25722 Wardell BB, et al., Aod1, the immunoregulatory locus controlling abrogation of tolerance in neonatal thymectomy-induced autoimmune ovarian dysgenesis, maps to mouse chromosome 16. Proc Natl Acad Sci U S A. 1995 May 23;92(11):4758-62
• All: 2 reference(s)