Tg(Wap-Mmp3)9Sym
Transgene Detail
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Symbol: |
Tg(Wap-Mmp3)9Sym |
Name: |
transgene insertion 9, Carolyn J Sympson |
MGI ID: |
MGI:2429538 |
Synonyms: |
M1-9, WAP-MMP-3 |
Transgene: |
Tg(Wap-Mmp3)9Sym Location: unknown
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Alliance: |
Tg(Wap-Mmp3)9Sym page
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Wap-Mmp3)9Sym expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
rat |
Mmp3 (171045) |
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Mutation details: Modified rat matrix metalloproteinase 3 (Mmp3) sequence was adjoined to a 2.4 kb murine Wap promoter fragment. The Mmp3 sequence contained a valine to glycine substitution mutation at codon 92, thereby conferring autoactivation. Immunocytochemical analysis identified abundant transgenic protein in mammary tissues in pregnant and lactating mice.
(J:18003)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:18003 Sympson CJ, et al., Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression. J Cell Biol. 1994 May;125(3):681-93 |
All: |
3 reference(s) |
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