Tg(Acp5-MCP)1Rood
Transgene Detail

Summary

• Symbol: Tg(Acp5-MCP)1Rood
• Name: transgene insertion 1, G David Roodman
• MGI ID: MGI:2429433
• Synonyms: mTRAP-hCD46
• Transgene: Tg(Acp5-MCP)1Rood Location: unknown
• Alliance: Tg(Acp5-MCP)1Rood page

Transgene origin

• Strain of Origin: (CB6F1 x (C57BL/6 x BALB/c))F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Acp5-MCP)1Rood expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CD46 (4179)

  Cd46	(MGI:1203290)

• Mutation details: Expression of human sequence encoding MCP in the mouse was achieved using the mouse Acp5 promoter region, active in cells of the osteoclast lineage. The transgenic sequence encoded the largest isoform that exhibits a high level of expression in human osteoclasts (MCP-C1). Founder mice contained approximately 3 copies of the transgenic construct. (J:71933)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:71933 Reddy SV, et al., Osteoclasts formed by measles virus-infected osteoclast precursors from hCD46 transgenic mice express characteristics of pagetic osteoclasts. Endocrinology. 2001 Jul;142(7):2898-905
• All: 1 reference(s)