Tmevd3^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Tmevd3^DBA/2J
• Name: Theiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 3; DBA/2J
• MGI ID: MGI:2389394
• QTL: Tmevd3 Location: unknown Genetic Position: Chr14, cM position of peak correlated region/allele: 20.88 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:47545

108 (DBA/2J x B10.D2)F2 mice were subjected to quantitative trait analysis (QTL) for chronic demyelinating disease caused by Theiler's murine encephalomyelitis (Tmevd3). DBA/2J mice are susceptibile to the disorder, B10.D2 mice are resistant. A significant association of the demyelinating phenotype with Chromosome 14 marker D14Mit54 was indicated. This QTL region was large and covered approximately 54 cMs. The authors observed two peaks within the QTL and suggested that two loci may be involved in the phenotype. This second locus is designated as Tmevd4.

References

• Original: J:47545 Bureau JF, et al., Chromosome 14 contains determinants that regulate susceptibility to Theiler's virus-induced demyelination in the mouse. Genetics. 1998 Apr;148(4):1941-9
• All: 1 reference(s)