Cons5^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Cons5^DBA/2J
• Name: consumption-saccharin intake 5; DBA/2J
• MGI ID: MGI:2389347
• QTL: Cons5 Location: Chr14:34032684-34066990 bp Genetic Position: Chr14, Syntenic

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:50271

841 male mice 56-125 days of ages from 20 BXD/Ty RI strains were used to map QTLs associated with ethanol-induced conditioned taste aversion behavior. Inbred strain DBA/2J exhibits increased sensitivity to ethanol compared to C57BL/6J and decreases consumption of an ethanol-paired distinctive taste (ethanol-induced taste aversion) in a dose dependent manner. Saccharin solution drinking water was used as the paired taste in this study. Cons5 (P<0.01, in linkage with Glud; 15.5 cM) mapped to Chromosome 14 at 15.5 cM and is associated with preconditioned saccharin intake.

References

• Original: J:50271 Risinger FO, et al., Ethanol-induced conditioned taste aversion in BXD recombinant inbred mice. Alcohol Clin Exp Res. 1998 Sep;22(6):1234-44
• All: 1 reference(s)