Pgct1^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Pgct1^C57BL/6J
• Name: primordial germ cell tumor locus 1; C57BL/6J
• MGI ID: MGI:2389316
• QTL: Pgct1 Location: Chr13:70820783-70820897 bp Genetic Position: Chr13, cM position of peak correlated region/allele: 35.97 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers resistance to germ cell tumors of the testes compared to 129S1/SvImJ.

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:63413

In crosses involving 129S3/SvImJ and C57BL/6J inbred mice a locus on mouse Chromosome 13 in the 129S3/SvImJ strain was found to be associated with male germ cell tumors of the testes. This locus designated as Pgct1 segregated significantly (-log(p) = 7.82) with D13Mit188. In adddition, regions within mouse Chromosomes 6, 9, and 12 also showed an association with the phenotype, however further linkage analysis indicated that these regions were not significant.

References

• Original: J:63413 Muller AJ, et al., A male germ cell tumor-susceptibility-determining locus, pgct1, identified on murine chromosome 13. Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8421-6
• All: 1 reference(s)