Bmd11^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Bmd11^C57BL/6J
• Name: bone mineral density 11; C57BL/6J
• MGI ID: MGI:2389165
• QTL: Bmd11 Location: Chr11:63319407-63319522 bp Genetic Position: Chr11, cM position of peak correlated region/allele: 39.47 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Inheritance: Other (see notes)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Notes

Bmd11 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:78754

Linkage analysis was performed on 986 (C57BL/6J x C3H/HeJ)F2 female animals using 107 microsatellite markers to identify QTLs associated with bone mineral density (BMD). Parental strain C3H/HeJ exhibits higher bone mineral density values compared to C57BL/6J. Bmd11 mapped to 31 cM on mouse Chromosome 11 with a peak LOD=6.76 at D11Mit242 in linkage to femoral BMD (and suggestive linkage to vertebral BMD.) C3H/HeJ-derived alleles confer an additively-inherited increase in femoral and vertebral BMD at Bmd11.

References

• Original: J:78754 Beamer WG, et al., Quantitative trait loci for femoral and lumbar vertebral bone mineral density in C57BL/6J and C3H/HeJ inbred strains of mice. J Bone Miner Res. 2001 Jul;16(7):1195-206
• All: 2 reference(s)