Cln3^tm1Mem
Targeted Allele Detail

Summary

• Symbol: Cln3^tm1Mem
• Name: CLN3 lysosomal/endosomal transmembrane protein, battenin; targeted mutation 1, Marcy MacDonald
• MGI ID: MGI:2388887
• Synonyms: Cln3^{deltaex7/8neo}
• Gene: Cln3 Location: Chr7:126170571-126184991 bp, - strand Genetic Position: Chr7, 69.16 cM
• Alliance: Cln3^tm1Mem page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79615
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 7 and 8 were replaced with a floxed neo cassette inserted by homologous recombination. (J:79615)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cln3 Mutation: 38 strains or lines available

References

• Original: J:79615 Cotman SL, et al., Cln3( Deltaex7/8) knock-in mice with the common JNCL mutation exhibit progressive neurologic disease that begins before birth. Hum Mol Genet. 2002 Nov 1;11(22):2709-21
• All: 1 reference(s)