Summary |
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Variant origin |
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Variant description |
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Notes |
Mapping and Phenotype information for this QTL, its variants and associated markersJ:5082824 BXD RI (recombinant inbred) strains were analyzed for loci associated with bone mineral density (BMD) and body weight in 12-week-old female animals. Progenitor strain C57BL/6 exhibits greater bone mass than progenitor strain DBA/2 at 84 days of age, but body weight is very similar between the 2 strains. After screening over 1500 informative markers on a BXD mapping panel 10 provisional QTLs associated with BMD mapped to 9 different chromosomes and await confirmation. Two of the most significant BMD QTLs (P = 0.0007), Bomd1, mapped to mouse Chromosome 7 at 44 cM (in linkage with D7Mit234), and Bomd2, mapped to mouse chromosome 14 at 2 cM (in linkage with Ptprg). Possible candidate genes for Bomd1 are the insulin-like growth factor I receptor (Igf1r), parathyroid hormone (Pth), and calcitonin (Calca, previously Ct). A possible candidate gene for Bomd2 is bone morphogenetic protein 4 (Bmp4). |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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