Nidds^SJL/NBom
QTL Variant Detail

Summary

• QTL variant: Nidds^SJL/NBom
• Name: non-insulin-dependent diabetes mellitus in SJL; SJL/NBom
• MGI ID: MGI:2388838
• QTL: Nidds Location: Chr4:115030777-129465915 bp Genetic Position: Chr4, Syntenic

Variant origin

• Strain of Specimen: SJL/NBom

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers diabetes susceptibility compared to NZO/HlBom. (J:78920)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Notes

Nidds is linked to severe hyperglycemia and beta cell loss. Interaction with NZO/HlBom-derived alleles at Nob1 (Chr.5) accelerates onset of diabetes on a high fat diet.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:78920

Linkage analysis was performed on 199 male NZO/HlBom x (SJL/NBom x NZO/HlBom)F1 backcross animals to identify QTLs associated with susceptibility to diabetes. Parental strain NZO is obese and susceptible to diabetes whereas parental strain SJL is lean and diabetes resistant. A QTL linked to severe hyperglycemia mapped to mouse Chromosome 4 from approximately 40 cM - 70 cM with peak linkage of LOD=9.9 at D4Mit278 (55.2 cM) and D4Mit203 (60 cM). This locus, Nidds (non-insulin-dependent diabetes mellitus inSJL), is also linked to beta cell loss, but not to obesity or early hyperinsulinemia. Heterozygosity for SJL-derived alleles at Nidds confers susceptibility to late onset diabetes in response to either a standard or high fat diet. Homozygosity for NZO/HlBom-derived alleles at Nod1, a previously identified obesity locus on mouse Chromosome 5, interacts with Nidds to accelerate onset of diabetes in response to a high fat diet. Nod1 did not show this effect on a standard diet.

J:64158

Linkage analysis was performed on 111 male and 96 female NZO/HlBom x (SJL/NBom x NZO/HlBom)F1 backcross animals to identify QTLs associated with susceptibility to diabetes. Parental strain NZO is obese and susceptible to diabetes whereas parental strain SJL is lean and diabetes resistant. 92 polymorphic markers were screened.

A locus associated with diabetes-related traits mapped to mouse Chromosome 4 between D4Mit278 (55.2 cM) and D4Mit232 (71 cM). This locus was named Nidds. Animals heterozygous at Nidds exhibit hyperglycemia, hypoinsulinemia, and reduced body weight.

References

• Original: J:78920 Plum L, et al., L. Plum et al.: The mouse diabetes susceptibility locus Nidd/SJL. Diabetologia. 2002 Jun;45(6):823-30
• All: 2 reference(s)