Rab3a^Ebd
Chemically induced Allele Detail

Summary

• Symbol: Rab3a^Ebd
• Name: RAB3A, member RAS oncogene family; early bird
• MGI ID: MGI:2388806
• Synonyms: Rab3a^-
• Gene: Rab3a Location: Chr8:71207328-71211323 bp, + strand Genetic Position: Chr8, 34.15 cM
• Alliance: Rab3a^Ebd page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A single base pair substitution of a guanine for an adenine at position 3144 results in a nonconservative substutution of a glycine residue for aspartic acid at amino acid position 77. Western analyisi of whole brain extracts showed the protein is reduced by 73% in homozygous mutant animals. (J:79562)
• Inheritance: Semidominant

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rab3a Mutation: 14 strains or lines available

References

• Original: J:79562 Kapfhamer D, et al., Mutations in Rab3a alter circadian period and homeostatic response to sleep loss in the mouse. Nat Genet. 2002 Oct;32(2):290-5
• All: 6 reference(s)