Rr275254^tm2.1Dhr
Targeted Allele Detail

Summary

• Symbol: Rr275254^tm2.1Dhr
• Name: regulatory region 275254; targeted mutation 2.1, David H Raulet
• MGI ID: MGI:2388608
• Synonyms: E^-, ECgamma1^-, Trgc1^tm2.1Dhr
• Gene: Rr275254 Location: Chr13:19402601-19404400 bp Genetic Position: Chr13, Syntenic
• Alliance: Rr275254^tm2.1Dhr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75624
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: This allele is derived from Rr275254^tm2Dhr. The loxP site flanked neomycin resistance gene cassette substituted in place of the Ecgamma 1 enhancer element was removed by crossing Tcrg-C1^tm2Dhr animals to a cre-deleter strain. (J:75624)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr275254 Mutation: 0 strains or lines available

References

• Original: J:75624 Xiong N, et al., Redundant and unique roles of two enhancer elements in the TCRgamma locus in gene regulation and gammadelta T cell development. Immunity. 2002 Mar;16(3):453-63
• All: 1 reference(s)