Tg(Hoxb7-RET-M918T)1Vpa
Transgene Detail

Summary

• Symbol: Tg(Hoxb7-RET-M918T)1Vpa
• Name: transgene insertion 1, Vassilis Pachnis
• MGI ID: MGI:2388560
• Synonyms: Hoxb7-Ret9-MEN2B
• Transgene: Tg(Hoxb7-RET-M918T)1Vpa Location: unknown
• Alliance: Tg(Hoxb7-RET-M918T)1Vpa page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Hoxb7-RET-M918T)1Vpa expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  RET (5979)

  Ret	(MGI:97902)

  Transgene codes for a protein with a methionine to threonine mutation.

• Mutation details: The transgene consists of a human RET cDNA encoding the RET9 isoform with a methionine to threonine substitution at position 918 (M918T) fused to mouse Hoxb7 promoter sequences (-1316 to +81). Mouse Hoxb7 promoter was used to drive expression of the transgene throughout the uretic bud branches. The M918T mutation is associated with the human disease MEN2Bsyndrome. (J:71588)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Trangenic founder mice were sacrificed at day E18.5 for analysis.

References

• Original: J:71588 de Graaff E, et al., Differential activities of the RET tyrosine kinase receptor isoforms during mammalian embryogenesis. Genes Dev. 2001 Sep 15;15(18):2433-44
• All: 1 reference(s)