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Targeted Allele Detail
Symbol: Slc22a8tm1Ngm
Name: solute carrier family 22 (organic anion transporter), member 8; targeted mutation 1, Sanjay K Nigam
MGI ID: MGI:2388472
Synonyms: Oat3-
Gene: Slc22a8  Location: Chr19:8568618-8589199 bp, + strand  Genetic Position: Chr19, 5.44 cM
Alliance: Slc22a8tm1Ngm page
Germline Transmission:  Earliest citation of germline transmission: J:78014
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 3 was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region putatively encoded transmembrane domain 2. Normal transcript was undetected by Northern blot analysis of RNA obtained from homozygous mutant kidney tissue. (J:78014)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc22a8 Mutation:  32 strains or lines available
Original:  J:78014 Sweet DH, et al., Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice. J Biol Chem. 2002 Jul 26;277(30):26934-43
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.13
The Jackson Laboratory