Klk8^tm1Lth
Targeted Allele Detail

Summary

• Symbol: Klk8^tm1Lth
• Name: kallikrein related-peptidase 8; targeted mutation 1, Richard Lathe
• MGI ID: MGI:2388384
• Gene: Klk8 Location: Chr7:43447001-43453250 bp, + strand Genetic Position: Chr7, 28.26 cM, cytoband B4
• Alliance: Klk8^tm1Lth page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71533
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacment of the region of exon 3 encoding the aspartic acid region of the catalytic site with a lacZ-neo cassette. The targeting construct introduces stop codons in all 3 reading frames. Northern blot analysis of brain RNA verified the absence of gene expression in homozygous mutant animals. X-gal staining of mutant brains did not detect any lacZ expression. (J:71533)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klk8 Mutation: 22 strains or lines available

References

• Original: J:71533 Davies B, et al., Loss of hippocampal serine protease BSP1/neuropsin predisposes to global seizure activity. J Neurosci. 2001 Sep 15;21(18):6993-7000
• All: 1 reference(s)